Page mise à jour le 07 octobre 2010

Medical Research

1. AMVF Presentation: our aims, how do we operate
2. Our Diseases
3. Medical Research
4. Glossary
5. The AMVF links
6. Help us, Make a donation


3. Medical Research :

Immediate medical needs

- Identify unknown thrombosis parameters.
- Make more simple tests available to identify known parameters, and in particular the myeloproliverative syndromes.
- Make more practical anticlotting drugs available.
- Provide more efficient and better tolerated treatments, in particular for blood disorders.
- Increase efficiency in the use of angioplasty or TIPS.
- Make therapeutic procedures (angioplasty and TIPS) more successful and less complicated.


Medical research development

- Understand why thrombosis occurs in the hepatic or portal veins and not anywhere else in the body.
- Understand why some blood diseases generate clotting.
- Understand the irreversible after-effects of thrombosis and how to prevent them.
- Understand how ascites builds up with Budd Chiari.
- Understand the natural mechanisms of compensation after a venous thrombosis, so that they can be stimulated.
- What are the impacts of hepatic vascular obstructions on the aggravation of frequent liver diseases like viral hepatitis, cirrhosis or alcoholic cirrhosis.


Taking into consideration patients' problems

- Ensure the medical follow-up of all patients, wherever they come from.
- Improve patients' comfort (pain management of ascites .... ) and support them.
- Improve information supplied to patients and to their relatives.
- Identify where the nearest specialised hospital for treatment is.
- Ease patients' difficulties so that they can get on with their everyday life.
- Consider the influence of the disease on family members and relatives.
- Ensure prompt reimbursements.


To develop this research

Against these diseases which affect around 3,000 people in France, We, patients and relatives, have decided to contribute in creating the

"Fund for Medical Study and Research"

As early as 2007, the Fund started paying for studies directly connected to these rare diseases.

The relevance of the studies, directly aimed at these rare diseases, is analyzed by our Scientific Board. This Board is under the directorship of the distinguished European specialist, Professor Dominique Valla, from Beaujon Hospital in Clichy (Paris suburbs).

Professor Valla will put forward concrete and immediate interventions. This information will be available to our members and on this website.

For the first year AMVF gave € 2000 for the molecular study of hepatic nodules occurring during the Vascular Diseases of the Liver (Budd-Chiari syndrome, portal vein agenesy, portal vein thrombosis, hepatoportal sclerosis)

The following year, in 2007, € 4000 were given by the AMVF fund for the study of the "significance of circulating micro particles, in patient with cirrhosis or Budd-Chiari syndrome, in the activation of hepatic stellate cells".

This year, the AMVF will support 2 new research programs:

- € 5000 are allocated to the test protocol on new anticoagulants and portal thrombosis

- Another € 5000 is given to the AFEF (Association conducting studies on livers diseases and promoting the Hepatology discipline in the French speaking areas) in order to contribute, as financial partner, to the THROMBOCIR study.

Thanks to your participation, we are hoping to be even more efficient in the near future.

Help us, Make a donation


Jak2...a medical discovery


Writer : Professor Dominique Valla Chairman of the AMVF Scientific Board

Myeloproliferative disorders include polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis. Unregulation of the production of blood cells from bone marrow stem cells is responsible of the disorders. A major complication, which is still not understood, is thrombosis. The risk for thrombosis developing in the splanchic area ( portal and hepatic veins ) is between 1 and 5 %. Conversely, a myeloproliferative disorder is present in 35% of patients with portal venous thrombosis and in 65 % of those with hepatic vein thrombosis There is no explanation for such a discrepancy. In a patient with splanchic vein thrombosis, it is essential to investigate for a myeloproliferative disorder. Diagnosis is difficult to make on the sole ground of usual clinical and laboratory investigations. Invasive examinations are necessary: bone marrow biopsy; bone marrow aspirate allowing for cultures to show that stem cells alone do not need the growth factor which is normally required for red blood cells production (spontaneous erythroblastic colony formation ); and the measurement of the total amount of red blood cells in the body ( red cell mass). All those investigations are complex, expensive, time consuming, and not standardized (specific expertise is necessary and is scarce ).

Appearing in Spring 2005, a study from William Vainchenker and Nicole Casadevall group showed that most of the myeloproliferative disorders are a consequence of a JAK2 protein gene mutation. In the progenitor blood cells, this protein acts as a regulator. Normally, the blood cells production is regulated by a specific " growth factor " : erythropoietin for red cells, GCSF (Granulocyte-Colony Stimulating Factor) and GMCSF (Granulocyte-Macrophage Colony-Stimulating Factor) for white cells, thrombopoietin for platelets. According to the needs, those growth factors are produced (e.g. erythropoietin in the case of anaemia ). They associate to the receptors of progenitor surface which then activates inside the progenitor the JAK2 protein and, by a cascade effect, starts the production of missing cells. The V617F mutation leads to a permanent activation of JAK2 which becomes independent from growth factor orders. The consequence is an unsuited and longstanding "myeloproliferation".

The implications of this discovery are of great importance:

1. Understanding the mechanism leading to the myeloproliferative disease.

2. A simple diagnosis test based on a mere blood sample.

3. A true hope of a treatment using a JAK2 inhibitor.


There are limits, however: almost 100% of cases of polycythemia vera are explained by the V617FJAK2 mutation but only 50 % for other myeloproliferative diseases. In the next future, a mere positive test for the mutation will permit a diagnosis of myeloproliferative disease . If the mutation is undetectable, bone marrow biopsy would be needed. Assessment of erythroid colony formation and measurement of the red cell mass would become unnecessary for making a diagnosis, although not for making a decision on treatment.

A last important word : we are dealing with a "somatic mutation" ( a mutation appearing during our life only in one bone marrow cell progenitor , at variance of to a " germinal mutation" which would be transmitted by paternal spermatozoids or maternal ovocytes.). This acquired mutation is therefore not transmissible. Myeloproliferative diseases are not inherited disorders

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